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Updated: Apr 15, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

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Multidrug Resistance Proteins (MRPs) and Cancer Therapy

Yun-Kai Zhang1, Yi-Jun Wang, Pranav Gupta

  • 1College of Pharmacy and Health Sciences, St. John's University, 8000 Utopia Parkway, Queens, NY, 11439, USA, yunkai.zhang12@stjohns.edu.

The AAPS Journal
|April 5, 2015
PubMed

Insights

Multidrug resistance proteins (MRPs) are key in cancer therapy by extruding chemotherapy drugs. Inhibiting MRPs shows promise for resensitizing cancer cells to chemotherapy, offering new treatment strategies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • ATP-binding cassette (ABC) transporters are crucial for membrane transport.
  • Multidrug resistance proteins (MRPs) are an ABC transporter subfamily involved in drug efflux.
  • MRPs contribute to multidrug resistance in cancer chemotherapy.

Purpose of the Study:

  • To review the structure, distribution, and functions of MRP1-MRP9.
  • To discuss the role of MRPs in cancer chemotherapy.
  • To highlight novel modulators targeting MRPs for cancer therapy.

Main Methods:

  • Literature review of scientific articles on MRPs.
  • Analysis of physiological and pharmacological roles of MRPs.
  • Summary of current research on MRP inhibitors.

Main Results:

  • MRPs actively extrude chemotherapeutic agents, leading to drug resistance.
  • Some MRPs play essential roles in normal physiological processes.
  • Modulating MRP function can re-sensitize cancer cells to chemotherapy.

Conclusions:

  • MRPs are significant targets in cancer therapy.
  • Developing MRP inhibitors is a promising strategy to overcome drug resistance.
  • Further research into MRP modulators could enhance chemotherapy efficacy.

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