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Updated: Apr 15, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Opioid-induced hyperalgesia after rapid titration with intravenous morphine: Switching and re-titration to

Sebastiano Mercadante1, Patrizia Ferrera2, Edoardo Arcuri3

  • 1Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S. Lorenzo 312, 90146, Palermo, Italy. terapiadeldolore@lamaddalenanet.it; 03sebelle@gmail.com.

Annals of Palliative Medicine
|April 6, 2015
PubMed
Abstract

Keywords:
Cancer painopioid switchingopioid titrationopioid-induced hyperalgesia

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