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Toxicity of checkpoint inhibitors

Rafael Aron Schmerling1

  • 1Medical Oncologist at Centro Oncológico Antonio Ermírio de Moraes, São Paulo, Brazil. schmerling@gmail.com.

Chinese Clinical Oncology
|April 6, 2015
PubMed

Immunologic checkpoint inhibitor is a new class of antineoplastic drugs which mechanism of action depends on the interaction with the immune system. The first in class was ipilimumab, anti-CTLA4, and soon the anti-PD1 (Programmed Death 1) and anti-PDL1 are expected to be available. Although the profile of adverse events is unique, they are predictable and, by complying with the guidelines available, the management of these drugs is safe in the great majority of patients. Here, it is provided a review of adverse events and their management.

Keywords:
Melanomacheckpointimmune-related adverse eventsimmunotherapyinhibitorstoxicity

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