Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

1.9K
Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
1.9K
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

1.2K
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
1.2K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

2.6K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.6K
Drug-Receptor Interaction: Antagonist01:28

Drug-Receptor Interaction: Antagonist

5.7K
An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or hormones, from binding to the receptor and triggering a cellular response. Such interaction effectively hinders the normal physiological processes mediated by the receptor, resulting in various pharmacological effects depending on the specific receptor targeted.
Antagonists can be classified as competitive or noncompetitive based on their...
5.7K
Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

1.3K
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NMR and proteomic analysis of Cornus officinalis extract reveals abundance of 5-hydroxymethylfurfural and induced expression of Nrf2 and superoxide dismutase-2 in 1.1B4 human pancreatic β-cells and murine islets.

Molecular and cellular endocrinology·2025
Same author

A spectroscopic liquid biopsy for the earlier detection of multiple cancer types.

British journal of cancer·2023
Same author

Recurrent neural networks for time domain modelling of FTIR spectra: application to brain tumour detection.

The Analyst·2023
Same author

Tranexamic Acid Associated With Less Wound Complications in Ankle and Hindfoot Surgery: Level III, Retrospective Cohort Study.

The Journal of the American Academy of Orthopaedic Surgeons·2022
Same author

Clinical validation of a spectroscopic liquid biopsy for earlier detection of brain cancer.

Neuro-oncology advances·2022
Same author

Rapid Spectroscopic Liquid Biopsy for the Universal Detection of Brain Tumours.

Cancers·2021
Same journal

Advancing global health economics and policy of palliative and end-of-life care: insights from Ireland, Norway, Finland, Argentina, and India.

Annals of palliative medicine·2026
Same journal

Immune-related adverse effects in palliative care clinic.

Annals of palliative medicine·2026
Same journal

Palliative care for patients with haematologic malignancies: challenges and opportunities.

Annals of palliative medicine·2026
Same journal

Metastatic brachial plexopathy presenting as radiation-induced plexopathy in metastatic lung cancer: a case report and literature review.

Annals of palliative medicine·2026
Same journal

Artificial intelligence in home-based serious illness care: a scoping review of applications supporting quality palliative care.

Annals of palliative medicine·2026
Same journal

Christian and Indian religions on palliative sedation: a scoping study.

Annals of palliative medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 15, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

9.9K

Dopamine receptor antagonists.

Howard S Smith1, Lorrain R Cox2, Benjamin R Smith3

  • 1Albany Medical College, Department of Anesthesiology, 47 New Scotland Avenue, MC-131, Albany, New York 12208, USA. smithh@mail.amc.edu.

Annals of Palliative Medicine
|April 6, 2015
PubMed
Summary
This summary is machine-generated.

Dopamine receptor antagonists are common antiemetics for nausea and vomiting. Clinicians often switch between these agents instead of combining them with other drug classes when ineffective.

Keywords:
Nauseabutyrophenonesdopamine receptor antagonistsmetoclopramidephenothiazinesvomiting

More Related Videos

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

3.7K
Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
05:51

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

4.6K

Related Experiment Videos

Last Updated: Apr 15, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

9.9K
Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

3.7K
Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
05:51

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

4.6K

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Gastroenterology

Background:

  • Intractable nausea and/or vomiting significantly impacts patient quality of life.
  • Dopamine receptor antagonists are a primary class of antiemetic medications.
  • Current clinical practice may involve switching between dopamine antagonists for refractory symptoms.

Purpose of the Study:

  • To evaluate the efficacy of switching versus adding antiemetic agents.
  • To explore optimal therapeutic strategies for intractable nausea and vomiting.

Main Methods:

  • Review of antiemetic prescribing patterns.
  • Analysis of treatment outcomes for different antiemetic regimens.

Main Results:

  • Dopamine receptor antagonists are frequently used but may not always be effective.
  • Clinicians sometimes switch between dopamine antagonists rather than adding other classes.

Conclusions:

  • Consideration of alternative antiemetic classes (e.g., 5-HT3, NK-1 antagonists) is crucial when dopamine antagonists fail.
  • Optimizing antiemetic therapy requires exploring combination strategies beyond dopamine receptor antagonist monotherapy.