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Mining the ACCENT database: a review and update.

Lindsay A Renfro1, Qian Shi2, Daniel J Sargent2

  • 1Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. renfro.lindsay@mayo.edu.

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Summary
This summary is machine-generated.

The Adjuvant Colon Cancer End Points (ACCENT) database pools data from over 33,000 patients in 25 trials. This resource enables significant scientific findings in early-stage colon cancer research.

Keywords:
Adjuvant Colon Cancer End Points (ACCENT) Groupcolon cancerdatabase

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Area of Science:

  • Oncology
  • Clinical Trials
  • Biostatistics

Background:

  • The Adjuvant Colon Cancer End Points (ACCENT) Group database was established to address research questions in early-stage colon cancer.
  • It aggregates individual patient-level data from numerous adjuvant colon cancer trials.

Purpose of the Study:

  • To describe the history, collaboration, construction, principles, and future of the ACCENT database.
  • To highlight the scientific findings derived from pooled data analysis.
  • To showcase the ACCENT database as a precedent for multi-trial data aggregation in cancer research.

Main Methods:

  • Pooling of individual patient-level data from 25 adjuvant colon cancer trials.
  • Inclusion of data from over 33,000 patients enrolled between 1977 and 2008.
  • Analysis of disease-free survival as a surrogate endpoint for overall survival.

Main Results:

  • The ACCENT database contains comprehensive data from a large cohort of early-stage colon cancer patients.
  • The database has facilitated significant scientific discoveries addressing various clinical questions.
  • A key finding demonstrated 3-year disease-free survival as a surrogate for 5-year overall survival.

Conclusions:

  • The ACCENT database is a valuable resource for advancing early-stage colon cancer research.
  • The collaborative model and data aggregation strategy have proven effective.
  • The ACCENT initiative serves as a model for similar large-scale data initiatives in other cancer types.