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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
C(3)-cyclopropyl cephems and carbacephems
D O Spry1, N J Snyder, J S Kasher
1Lilly Research Laboratory, Eli Lilly & Company, Indianapolis, Indiana 46285.
The Journal of Antibiotics
|November 1, 1989
Abstract:
A series of C(3)-cyclopropyl cephems and carbacephems has been prepared by palladium catalyzed addition of diazomethane to the corresponding C(3)-vinyl derivatives. The phenylglycyl cyclopropyl cephem derivatives exhibit better Gram-positive activity than cephalexin or cefaclor, while the aminothiazole oxime cyclopropyl cephem derivatives were not as active as the corresponding C(3)-vinyl cephems.

