[Immune status estimation algorithm in irritable bowel syndrome patients with food intolerance]

Area of Science:

• Immunology
• Gastroenterology
• Dietary Science

Context:

• Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder.
• Food intolerance is frequently observed in IBS patients, impacting their immune status.
• Evaluating immune markers is crucial for understanding IBS pathophysiology.

Purpose:

• To develop an algorithm for assessing the immune status in IBS patients with food intolerance.
• To investigate the relationship between food intolerance and immune system parameters in IBS.
• To evaluate the efficacy of a rotational diet based on immunoassay data.

Summary:

• Food intolerances, particularly to proteinaceous foods, were diagnosed in 59.5% of IBS patients.
• Immune analysis revealed increased allergen-specific IgG antibodies and reduced anti-inflammatory cytokines (IL-10, TGFβ1) in IBS patients with food intolerance.
• Rotational diet therapy, guided by immunoassay results, showed a 68% effectiveness rate, improving clinical symptoms and modulating immune markers.

Impact:

• This study provides a novel approach to evaluating immune status in IBS patients with food intolerance.
• Findings highlight the role of immune dysregulation in IBS and the therapeutic potential of targeted dietary interventions.
• The developed algorithm and diet strategy can aid clinicians in managing IBS patients with associated food intolerances.