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Higher frequency of methicillin resistant bacteria in children with familial mediterranean fever

Erhan Yengil, Cengiz Cevik, Ibrahim Silfeler

    JPMA. the Journal of the Pakistan Medical Association
    |April 7, 2015
    PubMed
    Abstract

    Insights

    Children with Familial Mediterranean Fever have higher rates of resistant bacteria in their nasal passages. This finding highlights potential risks for comorbidities associated with antibiotic resistance in this population.

    Area of Science:

    • Microbiology
    • Pediatrics
    • Genetics

    Background:

    • Familial Mediterranean Fever (FMF) is a genetic autoinflammatory disorder.
    • Children with FMF may be at increased risk for infections due to their condition or treatment.
    • Nasal carriage of resistant microorganisms is a growing public health concern.

    Purpose of the Study:

    • To investigate the prevalence of resistant microorganisms in the nasal mucosa of children diagnosed with Familial Mediterranean Fever.
    • To compare the rates of resistant bacteria colonization between FMF patients and healthy controls.

    Main Methods:

    • A case-control study was conducted with 73 children with FMF and 78 healthy controls.
    • Nasal swab samples were collected from all participants, excluding those with recent antibiotic or steroid use.
    • Standard microbiological methods were employed for strain identification and analysis of resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).

    Main Results:

    • Resistant bacteria were isolated from 63% of FMF cases compared to controls (p=0.003), with an odds ratio of 2.7.
    • Methicillin-resistant coagulase-negative staphylococcus and methicillin-resistant Staphylococcus aureus were identified in both groups.
    • In healthy controls, a history of hospitalization significantly increased the risk of carrying resistant bacteria (OR: 7.7).

    Conclusions:

    • Children with Familial Mediterranean Fever exhibit higher rates of nasal carriage of resistant bacteria.
    • The increased prevalence of resistant microorganisms suggests a heightened risk of comorbidities linked to antibiotic resistance in FMF patients.
    • Further research is warranted to understand the implications of these findings for FMF management and public health.

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