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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.9K
Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.3K

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Related Experiment Video

Updated: Apr 15, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

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Tumour induced osteomalacia.

Muhammad Qamar Masood, Nanik Ram, Syed Ahsan Ali

    JPMA. the Journal of the Pakistan Medical Association
    |April 7, 2015
    PubMed
    Summary

    Tumour-induced osteomalacia (TIO) is a rare condition causing bone pain and weakness due to high fibroblast growth factor 23 (FGF-23). Early diagnosis and treatment are crucial for potentially curable outcomes.

    Area of Science:

    • Endocrinology
    • Oncology
    • Metabolic Bone Disease

    Background:

    • Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome.
    • Characterized by bone pain, fractures, and muscle weakness.
    • Caused by elevated serum fibroblast growth factor 23 (FGF-23) levels.

    Observation:

    • FGF-23 is secreted by tumors, often small and difficult to locate.
    • Patients experience significant delays in diagnosis due to the occult nature of TIO.
    • A case report details a young male with progressive muscle pain and weakness.

    Findings:

    • The case highlights the diagnostic challenges of TIO.
    • Emphasizes the need for physician awareness of TIO in unexplained weakness.
    • Serum phosphate measurement is a key diagnostic step.

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    Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
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    Implications:

    • Increased physician awareness can lead to earlier TIO diagnosis.
    • Prompt diagnosis facilitates timely and potentially curative treatment.
    • Highlights the importance of considering rare paraneoplastic syndromes.