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Updated: Apr 15, 2026
07:55
Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
Published on: November 3, 2012
13.4K
[Ocular hypertension in herpes simplex keratouveitis]
Oftalmologia (Bucharest, Romania : 1990)
|April 7, 2015
Summary
Herpes simplex virus (HSV) commonly causes recurrent ocular infections, particularly anterior uveitis in adults. Prompt management of HSV-1 related keratouveitis is crucial to prevent complications like secondary glaucoma.
Area of Science:
- Ophthalmology
- Virology
- Immunology
Context:
- Herpes simplex virus (HSV) is a prevalent human pathogen, with 90% of adults seropositive.
- Recurrent HSV infections affect over a third of the population, influenced by host immune response.
- HSV type 1 (HSV-1) is the primary cause of infectious anterior uveitis in adults.
Purpose:
- To highlight the significant role of HSV-1 in infectious anterior uveitis.
- To discuss the pathogenesis and clinical manifestations of HSV-1 ocular infections.
- To emphasize the link between keratouveitis and secondary glaucoma.
Summary:
- HSV-1 is a leading cause of infectious anterior uveitis, accounting for 6-10% of cases.
- Ocular structures are susceptible to HSV-1 infection in adults.
- Over half of HSV-1 induced keratouveitis cases develop intraocular hypertension and secondary open-angle glaucoma.
Impact:
- Highlights the importance of timely diagnosis and management of HSV-1 ocular infections.
- Underscores the potential for severe visual impairment due to HSV-1 related complications.
- Emphasizes that effective inflammation control can lead to resolution of secondary glaucoma.
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