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Related Experiment Video

Updated: Apr 15, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

New cell sources for T cell engineering and adoptive immunotherapy.

Maria Themeli¹, Isabelle Rivière¹, Michel Sadelain¹

¹The Center for Cell Engineering, Immunology and Molecular Pharmacology and Chemistry Programs, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

|April 7, 2015

Summary

Advancing engineered T cell therapies requires exploring alternative cell sources beyond autologous manufacturing. Induced pluripotent stem cell-derived T cells offer a promising path toward off-the-shelf, genetically enhanced, and histocompatible cell therapies.

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Area of Science:

Immunology
Cell Therapy
Biotechnology

Background:

Engineered T cells, such as chimeric antigen receptor (CAR) T cells, show clinical promise.
Current CAR T-cell therapies often rely on autologous manufacturing, limiting scalability and accessibility.

Purpose of the Study:

To review emerging T cell engineering strategies utilizing alternative T cell sources.
To highlight innovations that could overcome limitations of autologous T cell manufacturing.

Main Methods:

Review of scientific literature on alternative T cell sources for T cell engineering.
Discussion of virus-specific T cells, T cell receptor-less allogeneic T cells, expanded lymphoid progenitors, and iPSC-derived T cells.

Main Results:

Alternative T cell sources can reduce reliance on autologous manufacturing.
These sources facilitate allogeneic cell transfer across histocompatibility barriers.
Induced pluripotent stem cell (iPSC)-derived T lymphocytes present a viable option for 'off-the-shelf' cell therapies.

Conclusions:

Exploring alternative T cell sources is crucial for advancing T cell therapies.
iPSC-derived T cells hold significant potential for creating readily available, genetically enhanced, and histocompatible cell therapy products.