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Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
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Dendritic cell functions: Learning from microbial evasion strategies.

Maria Rescigno1

  • 1Department of Experimental Oncology, European Institute of Oncology, Milan, Italy; Department of Health Sciences, School of Medicine, University of Milan, Milan, Italy.

Seminars in Immunology
|April 7, 2015
PubMed
Summary

Pathogens can manipulate dendritic cells (DCs), specialized antigen-presenting cells (APCs), to evade immune detection. Understanding these immune evasion tactics reveals crucial DC functions and molecular pathways essential for immunity and tolerance.

Keywords:
Dendritic cellsImmune evasionPathogensTolerance

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Area of Science:

  • Immunology
  • Cell Biology
  • Microbiology

Background:

  • Dendritic cells (DCs) are crucial antigen-presenting cells (APCs) initiating immune responses and tolerance.
  • DCs act as sentinels, distinguishing pathogens from harmless antigens to regulate immunity.
  • Pathogens can exploit DC plasticity, converting immunogenic APCs into tolerogenic ones, hindering pathogen clearance.

Purpose of the Study:

  • To review mechanisms used by pathogens to evade dendritic cell (DC) surveillance.
  • To highlight the importance of understanding pathogen-induced DC manipulation for immune system insights.
  • To identify molecular pathways in DCs affected by pathogen evasion strategies.

Main Methods:

  • Literature review of pathogen-DC interactions.
  • Analysis of immune evasion strategies employed by various pathogens.
  • Discussion of molecular pathways targeted by pathogens within DCs.

Main Results:

  • Pathogens employ diverse strategies to subvert DC functions.
  • DC adaptability can be hijacked, leading to suppressed immune responses.
  • Pathogen-induced DC modulation impacts host defense and pathogen clearance.

Conclusions:

  • Pathogen evasion tactics offer valuable insights into DC biology and function.
  • Understanding these mechanisms is key to developing novel immunotherapies.
  • Targeting pathogen-hijacked pathways in DCs could restore effective immune surveillance.