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Nalbuphine could decrease the rewarding effect induced by tramadol in mice while enhancing its antinociceptive

Rasha Abdel-Ghany1, Mahmoud Nabil1, Mohamed Abdel-Aal1

  • 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.

European Journal of Pharmacology
|April 7, 2015
PubMed
Summary

Nalbuphine effectively blocks the rewarding effects of tramadol, a common pain medication, by preventing dopamine release in the brain. This combination also enhances pain relief, suggesting nalbuphine as a potential treatment for tramadol abuse.

Keywords:
NalbuphinePsychological dependenceRewardTramadol

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Addiction Research

Background:

  • Nalbuphine, a mixed kappa-opioid agonist and mu-opioid partial agonist, is used to manage pain and reduce opioid dependence.
  • Tramadol is a widely prescribed analgesic with abuse potential due to its rewarding effects.

Purpose of the Study:

  • To investigate the impact of nalbuphine on the rewarding effects and antinociception of tramadol.
  • To evaluate nalbuphine's potential as a pharmacotherapy for tramadol abuse.

Main Methods:

  • Utilized the conditioned place preference (CPP) paradigm in a mouse model.
  • Administered nalbuphine and tramadol concurrently (7mg/kg and 70mg/kg, s.c., respectively).
  • Measured dopamine levels in the nucleus accumbens.

Main Results:

  • Co-administration of nalbuphine completely blocked tramadol-induced CPP.
  • Nalbuphine prevented the tramadol-induced increase in dopamine levels in the nucleus accumbens.
  • The combination of nalbuphine and tramadol enhanced antinociceptive effects.

Conclusions:

  • Nalbuphine significantly attenuates the rewarding properties of tramadol.
  • Nalbuphine administration potentiates the analgesic effects of tramadol.
  • Nalbuphine shows promise as a therapeutic agent for managing tramadol abuse and dependence.