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Updated: Apr 15, 2026

Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum

Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum

Published on: May 22, 2018

New diagnostic tools in schistosomiasis.

J Utzinger¹, S L Becker², L van Lieshout³

¹Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases

|April 7, 2015

Summary

This summary is machine-generated.

Accurate diagnostic tools are crucial for schistosomiasis elimination efforts. New target product profiles and updated diagnostic methods are essential for monitoring progress and achieving control program goals.

Keywords:

Antibody detection Kato–Katz Schistosoma circulating antigens control diagnosis elimination polymerase chain reaction serology urine filtration

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Area of Science:

Neglected tropical diseases
Parasitic diseases
Public health

Background:

Schistosomiasis affects over 250 million people globally, historically hindering control due to a lack of effective diagnostics.
Mass drug administration with praziquantel, initiated in 2001, bypassed diagnostic needs, slowing R&D for new tools.
The 2020 WHO Roadmap emphasizes schistosomiasis elimination, necessitating advanced diagnostic capabilities.

Purpose of the Study:

To define target product profiles for schistosomiasis diagnostics across various control program stages.
To review current advancements in schistosomiasis diagnostic technologies.
To address challenges in implementing novel diagnostic tools in clinical practice.

Main Methods:

Literature review of schistosomiasis control strategies and diagnostic advancements.
Analysis of diagnostic needs for different phases of schistosomiasis control programs.
Evaluation of emerging diagnostic techniques including microscopy, antigen detection, PCR, and morbidity markers.

Main Results:

Development of target product profiles tailored to specific control program needs.
Overview of current diagnostic tools: microscopy, rapid antigen tests, PCR, and morbidity markers.
Identification of key challenges and potential solutions for integrating new diagnostic technologies.

Conclusions:

Highly accurate diagnostics are indispensable for achieving schistosomiasis elimination goals.
The defined target product profiles will guide the development and implementation of necessary diagnostic tools.
Addressing implementation challenges is critical for the successful integration of novel schistosomiasis diagnostics into public health programs.