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Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

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Related Experiment Video

Updated: Apr 15, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Epstein-Barr virus-associated lymphomas.

Ewelina Grywalska¹, Jacek Rolinski¹

¹Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Poland.

Seminars in Oncology

|April 7, 2015

Summary

Epstein-Barr virus (EBV) drives cancer by expressing latent genes, particularly infecting B lymphocytes to cause B-cell lymphomas. Understanding these mechanisms is key to combating EBV-associated malignancies.

Area of Science:

Virology
Oncology
Immunology

Background:

Epstein-Barr virus (EBV) is the first identified human oncogenic virus.
EBV establishes lifelong latent infections, evading host immune responses.
Latent gene expression patterns dictate EBV's role in various cancers.

Purpose of the Study:

To elucidate the mechanisms of EBV-driven lymphomagenesis.
To characterize EBV-associated lymphomas.
To highlight EBV's tropism for B lymphocytes.

Main Methods:

Review of EBV latent gene expression.
Analysis of EBV's cellular tropism.
Discussion of EBV-induced B-cell transformation.

Main Results:

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Last Updated: Apr 15, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

EBV expresses specific latent genes (nuclear antigens, latent membrane proteins, non-coding RNAs) to maintain its genome and evade immunity.
Different latency patterns correlate with specific malignancies.
EBV primarily infects B lymphocytes, leading to B-cell lymphomas under certain conditions.

Conclusions:

EBV's ability to infect diverse cell types contributes to a variety of diseases.
EBV-dependent lymphomas arise from the transformation of B lymphocytes.
Understanding EBV latency mechanisms is crucial for cancer pathogenesis research.