Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling and Repair01:31

Bone Remodeling and Repair

10.7K
10.7K
Bone Remodeling01:40

Bone Remodeling

41.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>MetaHarmonizer</i>: robust biomedical metadata harmonization and a contamination control for inflated LLM performance on public benchmarks.

bioRxiv : the preprint server for biology·2026
Same author

Smooth Muscle Cell-Specific Expression of Cyclic Nucleotide Phosphodiesterase 10a Promotes the Development of Medial Artery Calcification.

Journal of the American Society of Nephrology : JASN·2026
Same author

Early Impacts of a Medicaid Value-Based Payment Policy on Quality of Care in a Large Population with Serious Mental Illness.

The journal of mental health policy and economics·2026
Same author

A pivotal Wnt antagonist role promoting digit joint specification by constraining Wnt activity.

Nature communications·2026
Same author

Large-scale manual curation and harmonization of metadata from metagenomic and cancer genomic repositories: challenges and solutions.

Database : the journal of biological databases and curation·2026
Same author

The Common Fund Data Ecosystem (CFDE).

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Apr 15, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

10.5K

Multiscale cartilage biomechanics: technical challenges in realizing a high-throughput modelling and simulation

Ahmet Erdemir1, Craig Bennetts1, Sean Davis2

  • 1Computational Biomodeling (CoBi) Core , Lerner Research Institute, Cleveland Clinic , Cleveland, OH 44195 , USA ; Department of Biomedical Engineering , Lerner Research Institute, Cleveland Clinic , Cleveland, OH 44195 , USA.

Interface Focus
|April 7, 2015
PubMed
Summary

Understanding cartilage and chondrocyte mechanics is crucial for evaluating tissue damage and developing interventions. This study outlines strategies for a high-throughput, multiscale computational framework to analyze these biomechanics.

Keywords:
cartilagechondrocyteextracellularfinite-element analysispericellularpost-processing

More Related Videos

Building Finite Element Models to Investigate Zebrafish Jaw Biomechanics
14:11

Building Finite Element Models to Investigate Zebrafish Jaw Biomechanics

Published on: December 3, 2016

10.6K
Biomechanical Testing of Murine Tendons
10:09

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

14.4K

Related Experiment Videos

Last Updated: Apr 15, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

10.5K
Building Finite Element Models to Investigate Zebrafish Jaw Biomechanics
14:11

Building Finite Element Models to Investigate Zebrafish Jaw Biomechanics

Published on: December 3, 2016

10.6K
Biomechanical Testing of Murine Tendons
10:09

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

14.4K

Area of Science:

  • Biomechanics
  • Computational Biology
  • Tissue Engineering

Background:

  • Articular cartilage damage is linked to fiber architecture failure and chondrocyte injury.
  • Understanding cartilage mechanics is vital for healthy/diseased states and developing interventions.
  • Multiscale biomechanical factors influence the cartilage mechanical environment.

Purpose of the Study:

  • To summarize strategies for addressing technical challenges in post-processing simulations of cartilage and chondrocyte mechanics.
  • To establish foundations for a high-throughput multiscale analysis framework.
  • To enable individualized comprehension of healthy and diseased cartilage function.

Main Methods:

  • Utilized finite-element method for joint-tissue level simulations to analyze contact and field mechanics.
  • Employed tissue-cell scale simulations, driven by macroscale data, to predict chondrocyte deformation and matrix mechanics.
  • Developed automated methods for generating regional and tissue-cell scale models, including parametric representations and automated architecture generation.

Main Results:

  • Demonstrated automated generation of regional articular contact models and tissue-cell scale models.
  • Showcased post-processing scripts for extracting biphasic mechanical metrics and cell deformation metrics.
  • Verified the necessity of a second-order data passing scheme and evaluated microscale representative volume size effects.

Conclusions:

  • The summarized tools offer a framework for high-throughput exploration of cartilage biomechanics.
  • This framework enables minimally supervised model generation and multiscale biomechanical metric prediction.
  • The approach facilitates analysis from joint regions down to individual chondrocytes.