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Coupling intercellular molecular signalling with multicellular deformation for simulating three-dimensional tissue

Satoru Okuda1, Yasuhiro Inoue2, Tadashi Watanabe2

  • 1Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047 , Japan ; Department of Biomechanics, Institute for Frontier Medical Sciences , Kyoto University , 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507 , Japan.

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|April 7, 2015
PubMed
Summary
This summary is machine-generated.

This study introduces a 3D vertex model to simulate how biochemical signals and mechanical forces drive tissue development (morphogenesis). The model reveals how cell signaling and tissue deformation are coupled, impacting growth patterns.

Keywords:
3D vertex modelcomputational simulationdevelopmental biomechanicsmechanochemical couplingmorphogen transportmulticellular morphogenesis

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Area of Science:

  • Developmental Biology
  • Biophysics
  • Computational Biology

Background:

  • Multicellular structures form through complex biochemical and mechanical interactions.
  • Diffusible signaling molecules create spatial-temporal patterns in cell status and differentiation.
  • Cellular activities like contraction and apoptosis dynamically couple biochemical patterning with tissue deformation.

Purpose of the Study:

  • To investigate the unknown mechanisms linking cellular activities, tissue deformation, and biochemical patterning.
  • To propose a novel computational framework for modeling these mechanochemical couplings.
  • To explore emergent phenomena in three-dimensional (3D) multicellular morphogenesis.

Main Methods:

  • Developed a novel 3D vertex model to represent molecular signaling within mechanically deforming cells.
  • Modeled the transport of signaling molecules between adjacent cells based on their density.
  • Simulated signal-dependent epithelial growth to observe tissue morphogenesis.

Main Results:

  • The model successfully simulated various tissue morphogenesis outcomes, including growth arrest, expansion, invagination, and evagination.
  • Observed autonomous suppression of tissue growth during expansion due to diffusion-driven dilution of growth molecules.
  • Demonstrated dynamic coupling between 3D multicellular deformations and biochemical patterning.

Conclusions:

  • The proposed 3D vertex model effectively captures the interplay between biochemical signaling and mechanical deformation in morphogenesis.
  • The findings highlight the role of molecular diffusion in regulating tissue growth dynamics.
  • The model serves as a valuable tool for predicting emergent phenomena in mechanochemically coupled systems.