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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

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Aggressive B-cell lymphomas: a review and practical approach for the practicing pathologist.

Michael T Schmidt¹, Qin Huang, Serhan Alkan

¹Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

Advances in Anatomic Pathology

|April 7, 2015

Summary

Pathologists can now better diagnose and report on diffuse large B-cell lymphoma (DLBCL) and aggressive B-cell lymphomas. This review covers key concepts, testing, and molecular insights for improved patient treatment strategies.

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Area of Science:

Hematology
Oncology
Pathology

Background:

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy requiring updated diagnostic and reporting approaches.
Recent advancements necessitate a practical guide for pathologists at all training levels.

Purpose of the Study:

To provide a comprehensive and practical approach to diagnosing and reporting DLBCL and aggressive B-cell lymphomas.
To discuss current testing modalities and their prognostic significance for guiding therapy.

Main Methods:

Review of recent scientific literature and clinical guidelines.
Synthesis of information on diagnostic criteria, prognostic markers, and molecular alterations.

Main Results:

Key concepts and essential testing modalities for DLBCL diagnosis are outlined.
Prognostic information relevant to chemotherapeutic regimens is highlighted.
Insights into lymphomagenesis, signaling pathways, and molecular targets are presented.

Conclusions:

Updated approaches to DLBCL diagnosis and reporting are crucial for effective patient management.
Understanding molecular alterations offers potential for future targeted therapies in aggressive lymphomas.