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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Related Experiment Video

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[Age related dehydroepiandrosterone decrease: clinical significance and therapeutic interest].

Nikolaos Samaras, Dimitrios Samaras, Alexandre Forster

    Revue Medicale Suisse
    |April 8, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Dehydroepiandrosterone (DHEA) levels decline with age, linked to diseases like osteoporosis and depression. DHEA supplementation shows promise for age-related conditions, but further research is needed for optimal use.

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    Area of Science:

    • Endocrinology
    • Gerontology
    • Biochemistry

    Context:

    • Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are abundant human steroids.
    • DHEA/DHEAS levels naturally decrease with aging.

    Purpose:

    • To review the role of DHEA/DHEAS in age-related diseases.
    • To evaluate the therapeutic potential and safety of DHEA administration for these conditions.

    Summary:

    • Age-related decline in DHEA/DHEAS is associated with conditions including falls, osteoporosis, depression, atherosclerosis, and sexual dysfunction.
    • DHEA supplementation has demonstrated positive effects on several age-related disorders with a good safety profile.
    • Misinformation regarding DHEA as an "elixir of youth" has led to inappropriate prescriptions.

    Impact:

    • Highlights the need for larger, longer-term studies to establish clear indications and treatment protocols for DHEA.
    • Emphasizes the importance of evidence-based prescribing to avoid misuse and ensure patient safety.
    • Contributes to a better understanding of DHEA's role in healthy aging and disease prevention.