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HIV Type 1 Subtype A1 Dominates in Armenia.
Vita Laga, Alexander Vasilyev, Ilya Lapovok
1Laboratory of T-Lymphotropic Viruses, Ivanovsky Institute of Virology, Gamaleya 16, 123098 Moscow, Russia. mrbobkova@mail.ru.
Current HIV Research
|April 8, 2015
Summary
The most prevalent human immunodeficiency virus type 1 (HIV-1) subtype in Armenia is A1, with low drug resistance in treatment-naïve patients. Continued surveillance is crucial for managing HIV infection effectively.
Area of Science:
- Molecular epidemiology
- Virology
- Public Health
Background:
- Limited data exists on the molecular epidemiology of HIV-1 in Armenia.
- Understanding HIV-1 subtype distribution and drug resistance is vital for effective public health strategies.
Purpose of the Study:
- To determine the distribution of HIV-1 subtypes in Armenia.
- To assess HIV drug resistance in treatment-naïve patients.
Main Methods:
- Phylogenetic analysis of partial pol gene sequences.
- Population sequencing and HIV-1 tropism inference from env V3-loop sequences.
- Study involved 78 patients in Armenia and Russia (2009-2013).
Main Results:
- Subtype A1 was the most prevalent (92.3%), followed by subtype B (3.9%).
- HIV-1 tropism showed a near equal distribution of R5 (48.1%) and X4 (51.9%) variants.
- Low prevalence of drug resistance (1.5%) was observed in treatment-naïve patients.
Conclusions:
- HIV-1 genetic variants in Armenia are influenced by epidemics in Russia and other FSU countries.
- Ongoing surveillance of HIV-1 subtypes and drug resistance is essential for managing HIV infection in Armenia.
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