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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Updated: Apr 15, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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The WNT system: background and its role in bone.

U H Lerner1,2, C Ohlsson1

  • 1Centre for Bone and Arthritis Research, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Journal of Internal Medicine
|April 8, 2015
PubMed
Summary

WNT signalling pathways regulate bone mass. Targeting WNT inhibitors shows promise for osteoporosis treatment by promoting bone formation and resorption.

Keywords:
WNTboneosteoblastosteoclastsclerostin

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Bone Biology

Background:

  • WNTs are extracellular proteins crucial for embryonic development and cancer.
  • WNT signalling pathways are increasingly recognized for their roles in diverse biological processes.
  • Recent evidence highlights WNT signalling's critical role in maintaining trabecular and cortical bone mass.

Purpose of the Study:

  • To provide a historical overview of WNT discoveries.
  • To describe canonical and noncanonical WNT signalling pathways.
  • To summarize WNTs' regulation of bone mass, focusing on bone formation and resorption.

Main Methods:

  • Literature review of WNT signalling pathways.
  • Analysis of preclinical and clinical evidence on WNTs and bone mass.
  • Review of drug development targeting WNT pathways for bone disorders.

Main Results:

  • WNT signalling pathways are essential for regulating both trabecular and cortical bone.
  • WNTs influence bone mass by modulating bone formation and resorption processes.
  • Targeting WNT signalling presents a promising therapeutic strategy for bone diseases.

Conclusions:

  • Understanding WNT pathways offers opportunities for developing bone-specific drugs.
  • Neutralizing bone-specific WNT inhibitors is a potential anabolic treatment for osteoporosis.
  • WNT signalling is a key target for enhancing bone mass and treating bone loss.