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Effect of long-term Helicobacter pylori infection on growth of children: a cohort study
Celebi Kocaoglu1, Ahmet Ozel2, Mustafa Cayci3
1Department of Pediatrics, Konya Education and Research Hospital, 42090, Meram, Konya, Turkey. celebikocaoglu@hotmail.com.
Insights
Long-term Helicobacter pylori (H. pylori) infection negatively impacts children's growth. Prolonged exposure significantly reduces height and weight velocity scores in infected children.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Growth and Development
Background:
- Helicobacter pylori (H. pylori) infection's effect on child growth is debated.
- Investigating the long-term impact of H. pylori on pediatric height and weight.
Purpose of the Study:
- To determine the association between H. pylori infection duration and growth parameters in children.
- To analyze the impact on height and weight velocity scores based on infection exposure time.
Main Methods:
- 200 children (7-18 years) with dyspepsia were grouped by H. pylori status (positive/negative).
- Infection duration categorized into three groups: ≤1.5 months, >1.5-6 months, and >6 months.
- Anthropometric measurements and urea breath tests were conducted every six months.
Main Results:
- H. pylori positive children showed significantly lower mean growth velocity scores compared to H. pylori negative children (P=0.012).
- Children with infection exposure >6 months (group 3) had significantly lower growth velocity scores than groups 0 and 1 (P=0.005 and P=0.041).
- Group 3 exhibited significantly lower weight scores than group 1.
Conclusions:
- Prolonged H. pylori infection duration is associated with negative effects on height and weight in children.
- The study highlights a dose-dependent relationship between H. pylori exposure and impaired growth.
Background:
The effects of Helicobacter pylori (H. pylori) infection on growth are a controversial issue. We investigated the effects of long-term H. pylori infection on height and weight in children.
Methods:
A total of 200 children of 7-18 years old suffering from dyspeptic complaints were classified into two groups: H. pylori positive and negative groups, respectively. Whether the infection was impoved was followed up while performing urea breath test, and according to exposure time to the infection, the children were further divided into group 1 (≤1.5 months), group 2 (>1.5-≤6 months) and group 3 (>6 months). Antropometric measurements were obtained and repeated every six months.
Results:
Mean growth velocity scores in the H. pylori positive and negative groups were 0.49±3.85 [95% confidence interval (CI): -0.21-1.18] and 1.98±4.42 (95% CI: 1-2.96), respectively. The difference between both groups was statistically significant (P=0.012). Mean growth velocity scores in groups 1, 2 and 3 were 0.96±3.84, 0.16±4.51 and -0.85±3.09, respectively. Mean growth velocity scores of group 3 were significantly lower than those of groups 0 and 1 (P=0.005 and P=0.041). The mean weight scores in group 3 were similar to those in group 2, but the scores in group 3 were significantly lower than those in group 1 (-1.75±1.05, -1.21±1.37 and -0.88±1.49, respectively).
Conclusion:
As the duration of exposure is prolonged in children with H. pylori infection, the negative effect of the infection on both height and weight is evident.
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