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Juxtamembrane contribution to transmembrane signaling

Wei Deng1, Renhao Li1

  • 1Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, 30322.

Biopolymers
|April 8, 2015
PubMed

Signaling across the cell membrane mediated by transmembrane receptors plays an important role in diverse biological processes. Recent studies have indicated that, in a number of single-span transmembrane receptors, the intracellular juxtamembrane (JM) sequence linking the transmembrane helix with the rest of the cytoplasmic domain participates directly in the signaling process via several novel mechanisms. This review briefly highlights several modes of JM dynamics in the context of signal transduction that are shared by different types of transmembrane receptors.

Keywords:
juxtamembraneproteinlipid interactionsignal transductiontransmembrane receptor

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