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Lymph node status in inflammatory breast cancer.

Julie S Wecsler1, Welela Tereffe, Rose C Pedersen

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Positive lymph node status significantly reduces overall survival in inflammatory breast cancer (IBC). However, estrogen/progesterone receptor positivity and combined surgery/radiation therapy improve outcomes for node-positive IBC patients.

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Area of Science:

  • Oncology
  • Breast Cancer Research
  • Cancer Prognostics

Background:

  • Positive lymph node (LN) status is a known adverse prognostic factor in breast cancer.
  • The prognostic impact of lymph node status in inflammatory breast cancer (IBC) remains under-evaluated.

Purpose of the Study:

  • To investigate the association between lymph node status and overall survival (OS) in patients with non-metastatic inflammatory breast cancer.
  • To identify factors influencing survival in node-positive IBC patients.

Main Methods:

  • Utilized the Surveillance, Epidemiology, and End Results (SEER) 18 registry for data from 761 non-metastatic IBC patients (2004-2008).
  • Employed Kaplan-Meier survival analysis and Cox proportional hazard regression.
  • Assessed associations between lymph node status, estrogen/progesterone receptor (ER/PR) status, treatment, and OS.

Main Results:

  • Positive lymph node status was significantly associated with decreased OS (p < 0.001).
  • Five-year survival rates were 49% for LN-positive and 66% for LN-negative patients.
  • In node-positive patients, ER/PR positivity (p=0.025, p=0.007) and combined surgery/radiation therapy (p=0.002) improved OS.

Conclusions:

  • Positive lymph node status is a critical adverse prognostic factor in inflammatory breast cancer.
  • Estrogen/progesterone receptor positivity and multimodal treatment (surgery plus radiation) enhance survival outcomes in node-positive IBC.
  • Further research is needed to elucidate IBC biology and optimize treatment strategies.