[Neuropathology of cerebral cortices in neurodegenerative disorders]

Clinical symptoms and signs are important keys to detect cortical lesions of neurological disorders. Each disease presents with characteristic cortical lesions and distributions of abnormal inclusions. In the cerebral cortices, neuronal and glial inclusions consist of abnormally aggregated proteins, such as tau or TDP-43, which are disease-specific. However, neurological disorders span across a wide spectrum and individual variations exist in within populations of the same disease. Therefore, knowledge about disease-specific pathologies may provide useful guidelines for differential diagnosis of cortical lesions occurring in neurological diseases.