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Rapid development of pancreatitis following reuse of 6-mercaptopurine
1Division of Gastroenterology, University of Medicine of New Jersey-Robert Wood Johnson (Rutgers) Medical School, New Brunswick 08903-0019.
Journal of Clinical Gastroenterology
|December 1, 1989
Abstract:
A patient with Crohn's disease developed acute pancreatitis 4 h after retaking one 50 mg dose of orally administered 6-mercaptopurine (6-MP). All seven previously reported patients who were rechallenged with 50 mg or more of 6-MP developed pancreatitis within 48 h. These findings suggest that 6-MP can produce pancreatitis due to an idiosyncratic immune-mediated response. Patients with this complication should not reuse 6-MP.