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Developing a Rat Model for Bipolar Disorder
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Life expectancy in bipolar disorder.

Lars Vedel Kessing1, Eleni Vradi2, Per Kragh Andersen2

  • 1Psychiatric Center Copenhagen, Department O, University of Copenhagen, Copenhagen, Denmark.

Bipolar Disorders
|April 8, 2015
PubMed
Summary
This summary is machine-generated.

Life expectancy for individuals with bipolar disorder (BD) is reduced, particularly in early and mid-adulthood. This study refines previous estimates, showing a significant but less drastic decrease in lifespan for BD patients.

Keywords:
agebipolar disordergenderlife expectancymaniamortality

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Area of Science:

  • Psychiatry
  • Public Health
  • Epidemiology

Background:

  • Previous estimates of life expectancy reduction in bipolar disorder (BD) are based on early-onset data, potentially overestimating the impact for the general BD population.
  • Most individuals diagnosed with BD experience a later onset of the illness, necessitating age-specific life expectancy calculations.

Purpose of the Study:

  • To determine the remaining life expectancy for patients diagnosed with bipolar disorder across various age groups.
  • To provide a more accurate assessment of life expectancy reduction in BD by considering different age of onset.

Main Methods:

  • Utilized nationwide Danish registers of psychiatric inpatient and outpatient contacts from 1970 to 2012.
  • Calculated remaining life expectancies for individuals aged 15 to 75 years alive in 2000, comparing those with BD to the general population.

Main Results:

  • For patients aged 25-45 years, remaining life expectancy decreased by 12.0-8.7 years (males) and 10.6-8.3 years (females).
  • The ratio of remaining life expectancy in BD patients compared to the general population decreased with age.
  • This indicates that life-years are lost predominantly during early and mid-adulthood for individuals with BD.

Conclusions:

  • Life expectancy for individuals with bipolar disorder is substantially reduced, though less than previously estimated.
  • The onset of significant life-year loss in bipolar disorder occurs during early and mid-adulthood.