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Updated: Apr 15, 2026
Assessing Functional Performance in the Mdx Mouse Model
Published on: March 27, 2014
Age-related T2 changes in hindlimb muscles of mdx mice
Ravneet S Vohra1, Sunita Mathur2, Nathan D Bryant3
1Department of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Introduction:
Magnetic resonance imaging (MRI) was used to monitor changes in the transverse relaxation time constant (T2) in lower hindlimb muscles of mdx mice at different ages.
Methods:
Young (5 weeks), adult (44 weeks), and old mdx (96 weeks), and age-matched control mice were studied. Young mdx mice were imaged longitudinally, whereas adult and old mdx mice were imaged at a single time-point.
Results:
Mean muscle T2 and percent of pixels with elevated T2 were significantly different between mdx and control mice at all ages. In young mdx mice, mean muscle T2 peaked at 7-8 weeks and declined at 9-11 weeks. In old mdx mice, mean muscle T2 was decreased compared with young and adult mice, which could be attributed to fibrosis.
Conclusions:
MRI captured longitudinal changes in skeletal muscle integrity of mdx mice. This information will be valuable for pre-clinical testing of potential therapeutic interventions for muscular dystrophy.
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