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Severe acute abdomen caused by symptomatic Meckel's diverticulum in three children with trisomy 18

Anri Hayashi1, Tomohiro Kumada1, Oki Furukawa2

  • 1Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Japan.

American Journal of Medical Genetics. Part A
|April 8, 2015
PubMed

Insights

Meckel's diverticulum (MD) in trisomy 18 patients can cause serious abdominal issues like intussusception and volvulus. Early suspicion and surgical intervention are crucial for managing symptomatic MD in these children.

Area of Science:

  • Pediatric Surgery
  • Medical Genetics
  • Gastroenterology

Background:

  • Meckel's diverticulum (MD) is a common congenital gastrointestinal anomaly.
  • Trisomy 18 is frequently associated with MD, but clinical data in affected infants is scarce.

Observation:

  • Three pediatric cases of trisomy 18 with symptomatic MD are presented.
  • Manifestations included intussusception, intestinal volvulus, and gastrointestinal bleeding.
  • All patients underwent surgical management.

Findings:

  • One patient died from a pulmonary hypertensive crisis post-surgery.
  • The other two patients recovered without recurrent abdominal symptoms.
  • Symptomatic MD requires high suspicion in trisomy 18 patients with acute abdomen.

Implications:

  • Surgical treatment for symptomatic MD is feasible in trisomy 18 patients.
  • Careful consideration of prognosis and postoperative complications is essential.
  • This case series highlights the importance of recognizing MD in trisomy 18 infants presenting with abdominal distress.

Keywords:
18 trisomyMeckel'sacute abdomenchildrendiverticulum

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