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Wen Dan Decoction for hemorrhagic stroke and ischemic stroke
Jia-Hua Xu1, Yan-Mei Huang2, Wei Ling2
1Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Fangchenggang Hospital of Traditional Chinese Medicine, Guangxi 538021, China.
Complementary Therapies in Medicine
|April 8, 2015
Summary
Wen Dan Decoction (WDD), a traditional Chinese medicine, significantly improves neurological function and therapeutic efficacy in stroke patients. This formula shows promise for both ischemic and hemorrhagic stroke treatment.
Area of Science:
- Neurology
- Integrative Medicine
- Pharmacology
Background:
- Traditional Chinese Medicine (TCM) use for stroke is rising globally.
- Wen Dan Decoction (WDD) is a prominent TCM formula.
- Evidence for WDD in treating ischemic and hemorrhagic stroke requires synthesis.
Purpose of the Study:
- To systematically review and meta-analyze clinical evidence on WDD for stroke treatment.
- To evaluate WDD's efficacy in improving neurological deficits and overall therapeutic outcomes.
- To compare WDD with conventional Western medicine in stroke management.
Main Methods:
- Searched major databases (PubMed, CNKI, Wan Fang, Cochrane) and clinical trial registries up to February 2013.
- Included randomized controlled trials (RCTs) comparing WDD intervention with conventional medicine.
- Analyzed Neurological Functional Deficit Scores (NFDS) and therapeutic efficacy rates; used meta-regression for heterogeneity.
Main Results:
- Included 22 RCTs for ischemic stroke and 4 for hemorrhagic stroke (2214 patients total).
- WDD significantly improved NFDS compared to controls (mean difference = -3.40).
- WDD showed higher overall therapeutic efficacy and cure rates for both hemorrhagic (OR=3.39) and ischemic stroke (OR=3.31, OR=2.22).
Conclusions:
- Wen Dan Decoction demonstrates significant benefits in enhancing neurological function and overall therapeutic efficacy in post-stroke patients.
- WDD may act as a dual-action therapeutic agent, potentially addressing common mechanisms in cerebral hemorrhage and ischemia.
- This meta-analysis supports WDD as a valuable addition to stroke treatment strategies.
