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Caesarean Section has no impact on lung function at the age of 15 years
Irene Brüske1, Zhengcun Pei1,2, Elisabeth Thiering1,3
1Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environment Health, Neuherberg, Germany.
Insights
Children born via Caesarean Section (C-Section) do not face a higher risk of asthma or impaired lung function by age 15. This large birth cohort study found no significant long-term respiratory health differences.
Area of Science:
- Pediatric respiratory health
- Obstetrics and Gynecology
- Epidemiology
Background:
- Previous studies suggest a link between Caesarean Section (C-Section) and increased childhood asthma risk.
- This study investigates the long-term impact of C-Section on respiratory health in adolescents.
Purpose of the Study:
- To determine if delivery by C-Section affects adolescent lung function.
- To assess the risk of asthma development by age 15 in children born via C-Section.
Main Methods:
- A population-based prospective birth cohort of 1850 healthy, full-term newborns was followed.
- Data on delivery mode, asthma, and spirometry at age 15 were collected.
- Linear regression models analyzed associations between delivery mode and lung function.
Main Results:
- No statistically significant differences in lung function parameters were observed between adolescents born by C-Section and vaginal delivery.
- The risk of developing asthma by age 15 was not elevated for children born by C-Section (OR: 0.87; 95% CI: 0.57, 1.33).
Conclusions:
- Caesarean Section delivery was not associated with impaired lung function in adolescence.
- This study found no increased risk of asthma at age 15 for children born via C-Section in this cohort.
Background:
Epidemiological studies and meta-analyses have shown an increased risk of childhood asthma for children born by Caesarean Section (C-Section).
Objective:
To investigate the effect of delivery by C-Section on lung function and asthma in adolescence in a population-based prospective birth cohort of healthy full term newborns.
Methods:
Questionnaire data on mode of delivery and asthma as well as spirometric measurements were available for 1850 adolescents at the age of 15 years, who participated in a follow-up examination of the GINIplus study. Linear regression models were used to examine associations between mode of delivery and lung function parameters. Two reference populations (Lunokid and GLI) were used to calculate the standardized z-scores of lung function parameters.
Results:
The mean difference in lung function parameters for adolescents born by C-Section, compared to vaginal delivery was not statistically significant. The risk for developing asthma by the age of 15 years was not higher in children born by C-Section-OR: 0.87 (95% CI: 0.57, 1.33) adjusted for sex, age, study center, and parental education level.
Conclusion:
C-Section was not associated with impaired lung function or an increased risk of asthma at the age of 15 years in our birth cohort of healthy full term neonates.
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