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We developed two open-source software tools for non-rigid registration of MRI and transrectal ultrasound (TRUS) images. These tools support MRI-TRUS fusion for prostate interventions, achieving accurate results within 5 minutes.

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Area of Science:

  • Medical imaging
  • Image registration
  • Prostate interventions

Background:

  • MRI-TRUS fusion is crucial for guiding prostate interventions like biopsies and focal therapy.
  • Accurate non-rigid image registration is essential for effective MRI-TRUS fusion systems.
  • Existing solutions may lack open-source accessibility or novel registration approaches.

Purpose of the Study:

  • To introduce two novel open-source software tools for non-rigid registration of prostate MRI and transrectal ultrasound (TRUS) images.
  • To support the development of MRI-TRUS fusion image guidance for prostate interventions.
  • To provide accessible tools for research and clinical applications in prostate cancer treatment.

Main Methods:

  • Deformable registration of prostate segmentation distance maps using B-spline regularization.
  • Finite element-based deformable registration of segmentation surfaces, accommodating partial data.
  • Retrospective evaluation using clinical patient data, measuring computation time and Target Registration Error (TRE).

Main Results:

  • Both registration tools completed computations within 5 minutes.
  • Average TRE was approximately 3 mm, comparable to MRI slice thickness.
  • The developed software tools are available under nonrestrictive open-source licenses.

Conclusions:

  • Open-source tools for MRI-TRUS registration in prostate interventions are now available.
  • The novel registration approaches yield acceptable results, facilitating research and development.
  • These tools aim to reduce barriers in deploying interventional research solutions and enable easier comparison between tools.