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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
[Immunoanalytical profile of free tri-iodothyronine]
Radhouene Doggui1, Jacques Ingrand2
1Laboratoire de surveillance et épidémiologie nutritionnelles en Tunisie (Surven), Institut national de nutrition et de technologie alimentaire, Tunis, Tunisie.
Tri-iodothyronine (T3) is the active form of thyroid hormone at the nuclear cell level. About 80% of tri-iodothyronine is produced by peripheral deiodination of thyroxine. The determination of the free form of this hormone is useful for the diagnosis and the follow-up of hyperthyroidism. In routine clinical laboratories, immunoassays remain the most used technics. After recalling the main points related to the physiological data, the authors point out the possible errors during the analytical steps of the assay.
Tri-iodothyronine (T3) is the active form of thyroid hormone at the nuclear cell level. About 80% of tri-iodothyronine is produced by peripheral deiodination of thyroxine. The determination of the free form of this hormone is useful for the diagnosis and the follow-up of hyperthyroidism. In routine clinical laboratories, immunoassays remain the most used technics. After recalling the main points related to the physiological data, the authors point out the possible errors during the analytical steps of the assay.
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