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The relationship between rheumatoid factor levels and coronary artery lesion complexity and severity in patients with

Elnur Alizade1, Anıl Avcı1, Göksel Açar1

  • 1Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey.

Postepy W Kardiologii Interwencyjnej = Advances in Interventional Cardiology
|April 8, 2015
PubMed

Insights

Serum rheumatoid factor levels are higher in patients with more severe coronary artery disease. Rheumatoid factor is an independent risk factor for predicting the extent and complexity of coronary artery disease.

Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • The link between serum rheumatoid factor (RF) and coronary artery disease (CAD) severity remains understudied.
  • Understanding this relationship may offer insights into CAD pathogenesis and risk stratification.

Purpose of the Study:

  • To investigate the association between serum RF levels and the severity of CAD, as quantified by the SYNTAX score.
  • To determine if RF is an independent predictor of complex coronary artery disease in stable CAD patients.

Main Methods:

  • 268 patients with stable CAD undergoing coronary angiography were included.
  • Serum RF levels were measured, and the SYNTAX score was calculated to assess CAD complexity.
  • Patients were stratified into low (SYNTAX < 22) and intermediate/high (SYNTAX > 22) SYNTAX score groups.

Main Results:

  • Serum RF levels were significantly elevated in the intermediate/high SYNTAX score group compared to the low SYNTAX score group (16.4 ±9 vs. 11.36 ±5 IU/ml, p < 0.001).
  • RF showed a significant positive correlation with SYNTAX score (r = 0.411, p < 0.001) and CRP levels (r = 0.275, p < 0.001).
  • Multivariate analysis identified RF as an independent risk factor for intermediate/high SYNTAX scores (β = 0.101, p < 0.001).

Conclusions:

  • Serum RF levels are independently associated with the extent, complexity, and severity of coronary artery disease in stable patients.
  • An RF cut-off of 10.5 IU/ml demonstrated 69% sensitivity and 61% specificity for predicting high SYNTAX scores.
Abstract

Keywords:
SYNTAX scoreautoantibodiesinflammationrheumatoid factor

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