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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
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Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

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Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
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Related Experiment Video

Updated: Apr 15, 2026

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
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Metabolite profiling in posttraumatic stress disorder.

Alexander Karabatsiakis1, Gilava Hamuni1, Sarah Wilker1

  • 1Clinical & Biological Psychology, Ulm University, Albert-Einstein Allee 47, 89081 Ulm, Germany.

Journal of Molecular Psychiatry
|April 8, 2015
PubMed
Summary
This summary is machine-generated.

Metabolite profiling reveals significant changes in lipids and endocannabinoid signaling in individuals with posttraumatic stress disorder (PTSD). This approach aids in discovering biological pathways and developing diagnostic biomarkers for PTSD.

Keywords:
Biological pathwaysGlycerophospholipidMass spectrometryMetabolite profilingPalmitoylethanolamidePosttraumatic stress disorder

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Area of Science:

  • Biochemistry
  • Neuroscience
  • Psychiatry

Background:

  • Traumatic stress elevates the risk of posttraumatic stress disorder (PTSD) and associated physical health issues.
  • Understanding the biomolecular mechanisms of PTSD remains a challenge.
  • Metabolite profiling offers a hypothesis-free approach to uncover biological pathways implicated in PTSD.

Purpose of the Study:

  • To conduct the first metabolite profiling study in posttraumatic stress disorder (PTSD).
  • To identify metabolites in peripheral blood serum associated with PTSD status.
  • To explore potential biological pathways involved in PTSD pathophysiology.

Main Methods:

  • Analysis of peripheral blood serum samples from 20 PTSD patients and 18 controls.
  • Utilized liquid chromatography (LC) coupled to Quadrupole/Time-Of-Flight (QTOF) mass spectrometry.
  • Employed univariate analyses and Partial Least Squares Discriminant Analysis (PLS-DA) for statistical identification of metabolites.

Main Results:

  • Identified thirteen significantly altered metabolites in PTSD patients, including four glycerophospholipids and one endocannabinoid signaling metabolite.
  • A panel of 19 metabolites achieved 85% accuracy in classifying PTSD.
  • A single glycerophospholipid demonstrated 82% accuracy in classifying PTSD.

Conclusions:

  • Metabolite profiling is a feasible and valuable tool for PTSD research.
  • Lipid-derived metabolites and endocannabinoid signaling pathways are implicated in the pathophysiology of trauma.
  • Findings suggest novel avenues for understanding and potentially diagnosing PTSD.