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Updated: Apr 15, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
Kawasaki disease with autoimmune hemolytic anemia
Dhwanee Thakkar1, Nita Radhakrishnan, P K Pruthi
1Pediatric Hematology Oncology and BMT Unit; and *Institute of Child Health; Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India. Correspondence to: Dr Anupam Sachdeva, Head of Department, Institute of Child Health, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110 060, India. anupampublications@gmail.com.
Background:
Association of autoimmune haemolytic anaemia has been seldom reported with Kawasaki disease.
Case Characteristics:
A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.
Observations:
Positive Direct Coombs test and coronary artery aneurysm on echocardiography. He was managed with steroids along with intravenous immunoglobulins and aspirin.
Outcome:
Early identification of the condition helped in the management.
Message:
Patients of autoimmune hemolytic anemia with unusual features such as prolonged fever, skin rash, and mixed antibody response in Coombs test should be evaluated for underlying Kawasaki disease as a possible etiology.
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