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Updated: Apr 15, 2026

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
Published on: July 30, 2014
Unconventional actins and actin-binding proteins in human protozoan parasites
C M Gupta1, S Thiyagarajan2, A A Sahasrabuddhe3
1Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India; Institute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City, Phase I, Bangalore 560100, India.
Abstract:
Actin and its regulatory proteins play a key role in several essential cellular processes such as cell movement, intracellular trafficking and cytokinesis in most eukaryotes. While these proteins are highly conserved in higher eukaryotes, a number of unicellular eukaryotic organisms contain divergent forms of these proteins which have highly unusual biochemical and structural properties. Here, we review the biochemical and structural properties of these unconventional actins and their core binding proteins which are present in commonly occurring human protozoan parasites.
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