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Updated: Apr 15, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Interaction of a green ester-bonded gemini surfactant with xanthine oxidase: Biophysical perspective
Mohd Akram1, Imtiyaz Ahmad Bhat1, Kabir-ud-Din2
1Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India.
Abstract:
A multi technique approach was utilized to explore the interaction between a novel green gemini surfactant, ethane-1,2-diyl bis(N,N-dimethyl-N-tetradecylammoniumacetoxy) dichloride (14-E2-14), with bovine milk xanthine oxidase (XO). Tensiometric, spectroscopic, microscopic and molecular modeling results demonstrate significant interaction and structural change of native xanthine oxidase upon 14-E2-14 combination. The results obtained in this study may be beneficial for scientists to calibrate conformation of the enzyme by novel biodegradable/green microstructures; consequently, it would likely add new impetus in understanding the treatment modes of various diseases like gout, hyperuricemia, liver and brain necrosis. Moreover, the 14-E2-14-XO interaction assists to unfurl new routes in the designing/selection of green-surfactant-protein mixtures widely used in food processing, cosmetics, and pharmaceutical industries.
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