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Updated: Apr 15, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Mild cognitive impairment is associated with poorer decision-making in community-based older persons
S Duke Han1, Patricia A Boyle, Bryan D James
1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois; Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois; Mental Health Care Group, Veterans Affairs Long Beach Healthcare System, Long Beach, California.
Objective:
To test the hypothesis that mild cognitive impairment (MCI) is associated with poorer financial and healthcare decision-making.
Design:
Community-based epidemiological cohort study.
Setting:
Communities throughout northeastern Illinois.
Participants:
Older persons without dementia from the Rush Memory and Aging Project (N = 730).
Measurements:
All participants underwent a detailed clinical evaluation and decision-making assessment using a measure that closely approximates materials used in real-world financial and healthcare settings. This allowed for measurement of total decision-making and financial and healthcare decision-making. Regression models were used to examine whether MCI was associated with a lower level of decision-making. In subsequent analyses, the relationship between specific cognitive systems (episodic memory, semantic memory, working memory, perceptual speed, visuospatial ability) and decision-making was explored in participants with MCI.
Results:
MCI was associated with lower total, financial, and healthcare decision-making scores after accounting for the effects of age, education, and sex. The effect of MCI on total decision-making was equivalent to the effect of more than 10 additional years of age. Additional models showed that, when considering multiple cognitive systems, perceptual speed accounted for the most variance in decision-making in participants with MCI.
Conclusion:
Persons with MCI may have poorer financial and healthcare decision-making in real-world situations, and perceptual speed may be an important contributor to poorer decision-making in persons with MCI.
Insights
Mild cognitive impairment (MCI) is linked to worse financial and healthcare decision-making. Perceptual speed is a key factor in these decision-making deficits in individuals with MCI.
Area of Science:
- Neuroscience
- Gerontology
- Cognitive Psychology
Background:
- Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia.
- Understanding the functional consequences of MCI is crucial for early intervention and support.
Purpose of the Study:
- To investigate the association between mild cognitive impairment (MCI) and financial and healthcare decision-making.
- To identify specific cognitive domains that contribute to decision-making deficits in individuals with MCI.
Main Methods:
- A community-based epidemiological cohort study involving 730 older adults without dementia.
- Decision-making was assessed using real-world financial and healthcare scenarios.
- Regression models analyzed the relationship between MCI, cognitive systems, and decision-making performance.
Main Results:
- Mild cognitive impairment (MCI) was significantly associated with poorer overall, financial, and healthcare decision-making.
- The impact of MCI on decision-making was comparable to over 10 additional years of aging.
- Perceptual speed emerged as the primary cognitive predictor of decision-making deficits in MCI.
Conclusions:
- Individuals with mild cognitive impairment (MCI) may exhibit impaired financial and healthcare decision-making in practical settings.
- Perceptual speed is a critical cognitive domain influencing decision-making abilities in persons with MCI.
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