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Updated: Apr 15, 2026
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Novel inflammatory biomarkers in primary hyperparathyroidism
M H E Christensen1, I S Fenne2, Y Nordbø3
1Department of Clinical ScienceUniversity of Bergen, Bergen, NorwayHormone LaboratoryDepartment of SurgeryHaukeland University Hospital, 5021 Bergen, NorwayDepartment of Surgical ScienceUniversity of Bergen, Bergen, NorwayKG Jebsen Center for Diabetes ResearchBergen, NorwayDepartment of Heart DiseaseHaukeland University Hospital, Bergen, Norway Department of Clinical ScienceUniversity of Bergen, Bergen, NorwayHormone LaboratoryDepartment of SurgeryHaukeland University Hospital, 5021 Bergen, NorwayDepartment of Surgical ScienceUniversity of Bergen, Bergen, NorwayKG Jebsen Center for Diabetes ResearchBergen, NorwayDepartment of Heart DiseaseHaukeland University Hospital, Bergen, Norway monika.christensen@k2.uib.no.
Objective:
Primary hyperparathyroidism (PHPT) has been associated with low-grade inflammation and increased risk of cardiovascular disease (CVD). The aim of the study was to investigate systemic levels of pro-inflammatory proteins that previously have not been examined in patients with PHPT. The selection of the pro-inflammatory biomarkers included in this study, MMP9, S100A4, S100A8/A9 and the receptors sCD14 and RAGE, was based on a previous microarray screen of mRNAs in adipose tissue from PHPT patients.
Design:
A prospective study was conducted on a total of 57 patients with PHPT and a control group of 20 healthy blood donors.
Methods:
PHPT patients with normalisation of serum calcium levels after parathyroidectomy were followed for 6 months. Forty-two patients participated in the longitudinal study, in which blood samples were taken at inclusion, and 1, 3 and 6 months after surgery.
Results:
We observed increased serum levels of MMP9 (P=0.029), S100A4 (P<0.001) and sCD14 (P=0.002) in the 57 patients with PHPT compared to the control-group. During 6 months of follow up, S100A4 (P=0.022) and sCD14 (0.002) decreased significantly, while serum levels of MMP9 increased (P=0.025).
Conclusions:
The results demonstrate an increased inflammatory response in PHPT patients shown by elevated MMP9, S100A4 and sCD14 at inclusion. During the 6 months of follow-up, MMP9 increased further, possibly due to the tissue repair process after parathyroidectomy. S100A4 and sCD14 decreased after surgery demonstrating a partial reversal of the systemic inflammation.
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