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Vestibular evoked myogenic potentials in pediatric patients with familial Mediterranean fever

Battal Tahsin Somuk1, Samet Özer2, Harun Soyalıc1

  • 1Department of Otorhinolaryngology, Gaziosmanpasa University, School of Medicine, Tokat, Turkey.

International Journal of Pediatric Otorhinolaryngology
|April 9, 2015
PubMed
Abstract

Insights

Familial Mediterranean Fever (FMF) is a chronic autoinflammatory condition. This study found no vestibular dysfunction in pediatric FMF patients using VEMP recordings, suggesting FMF does not impact vestibular function.

Area of Science:

  • Pediatric Rheumatology
  • Neurotology
  • Autoinflammatory Diseases

Background:

  • Familial Mediterranean Fever (FMF) is a genetic autoinflammatory disorder characterized by recurrent episodes of fever and inflammation.
  • The systemic inflammatory nature of FMF can affect multiple organ systems, raising concerns about potential impacts on neurological functions, including vestibular pathways.

Purpose of the Study:

  • To investigate the potential link between chronic inflammation in pediatric Familial Mediterranean Fever (FMF) and vestibular dysfunction.
  • To assess vestibular function in children diagnosed with FMF using Vestibular Evoked Myogenic Potential (VEMP) recordings.

Main Methods:

  • The study included 30 pediatric patients diagnosed with FMF and 20 healthy pediatric controls.
  • Participants underwent routine ear, nose, and throat examinations, transient-evoked otoacoustic emissions (TEOAE), and vestibular-evoked myogenic potential (VEMP) tests.
  • VEMP recordings were analyzed for latency and amplitude differences between FMF patients and controls.

Main Results:

  • All participants, including FMF patients and controls, had normal otoacoustic emission results.
  • Vestibular-evoked myogenic potential (VEMP) recordings were successfully obtained from all 60 ears of FMF patients and 40 ears of controls.
  • No statistically significant differences in VEMP latencies or amplitudes were observed between the pediatric FMF group and the healthy control group (p > 0.05).

Conclusions:

  • Vestibular-evoked myogenic potential (VEMP) testing was employed to evaluate vestibular function in pediatric patients with Familial Mediterranean Fever (FMF).
  • The study did not detect any alterations in VEMP parameters in pediatric FMF patients compared to healthy controls.
  • These findings suggest that FMF, despite its systemic inflammatory nature, does not appear to cause vestibular dysfunction in pediatric patients.
Keywords:
Familial Mediterranean feverTransient evoked otoacoustic emissionVestibular evoked myogenic potential

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