Lesions of intestinal epithelium by ingestion of bean lectins in rats

Wistar rats were submitted to the action of active lectins from common dry beans (Phaseolus vulgaris) and from jack beans (Canavalia ensiformis, DC). Raw common bean was offered to the rats in an otherwise balanced diet to make 10% protein as the sole protein source. A single dose of 20 mg of jack bean lectin (concanavalin A) was given by gastric intubation. Half of the rats receiving raw bean died within 22 days of experiment. Histological findings showed ulceration and necrosis of the intestinal villi in the surviving rats. In some cases the lesions reached also the submucosa. Gastric intubation of concanavalin A caused intense scaling off in the apical portion of the villi.