Related Experiment Video

Updated: Apr 15, 2026

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

3.8K

Characterization of Hip Morphology in Children With Mucopolysaccharidosis Types I and II

Elizabeth Ashby1, Markus Baker, Deborah M Eastwood

  • 1Department of Orthopaedic Surgery, Great Ormond Street Hospital for Children, London, UK.

Journal of Pediatric Orthopedics
|April 9, 2015
PubMed

Insights

Hip morphology in mucopolysaccharidoses (MPS) I and II shows significant hip migration and femoral head deformity. While acetabular dysplasia varies, some hips remain stable, potentially avoiding surgery.

Area of Science:

  • Orthopedics
  • Genetics
  • Pediatrics

Background:

  • Mucopolysaccharidoses (MPS) I and II are rare genetic disorders affecting skeletal development.
  • Hip morphology abnormalities are common in patients with MPS.

Purpose of the Study:

  • To describe the natural history of hip morphology in children with MPS I and MPS II.
  • To analyze changes in hip migration, femoral head sphericity, and acetabular dysplasia over time.

Main Methods:

  • Retrospective radiographic analysis of 88 hips in 44 children with MPS I and II.
  • Assessment of hip migration, femoral head sphericity, and acetabular dysplasia across different childhood ages.
  • Analysis of individual hip morphology changes and rates of progression.

Main Results:

  • High prevalence of hip migration and femoral head dysplasia in both MPS I and II.
  • Progressive hip migration observed in 75% of hips; progressive femoral head deformity in over 50%.
  • Variable acetabular dysplasia, not changing with time; hips were more dysplastic in MPS I than MPS II.

Conclusions:

  • Hip morphology in MPS I and II ranges from normal to severely dysplastic.
  • Some hips exhibit stability, suggesting surgical intervention may not always be necessary.
  • Slow disease progression allows for comprehensive treatment planning.
Abstract

More Related Videos

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

420
Author Spotlight: A Novel 3D-Printed Titanium Implant for Minimally Invasive Treatment of Hip Dysplasia in Young Dogs08:40

Author Spotlight: A Novel 3D-Printed Titanium Implant for Minimally Invasive Treatment of Hip Dysplasia in Young Dogs

Published on: April 19, 2024

4.1K

Related Concept Videos

Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.8K
Proteoglycans01:05

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
5.3K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
789
Glycosaminoglycans01:23

Glycosaminoglycans

Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
8.0K