Hormone Use, Reproductive History, and Risk of Lung Cancer: The Women's Health Initiative Studies

Ann G Schwartz1, Roberta M Ray, Michele L Cote

  • 1*Karmanos Cancer Institute and Department of Oncology, Wayne State University, Detroit, Michigan; †Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle Washington; ‡C.S. Mott Center for Human Growth and Development and Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan; §St. Joseph Mercy Oakland Hospital, Pontiac, Michigan; ‖Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington; ¶Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California; #Department of Medicine, University of California, Irvine, California; **Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; ††Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, Florida; ‡‡Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York; §§Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California; ‖‖Department of Epidemiology and Environmental Health, University of Buffalo School of Public Health and Health Professions, Buffalo, New York; and ¶¶Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford Cancer Institute, Stanford, California.

Summary

This study found that hormone therapy (HT) use under five years was associated with reduced lung cancer risk. However, evidence linking reproductive history to lung cancer risk remains weak, warranting further investigation.

Related Concept Videos

Statistical Methods for Analyzing Epidemiological Data01:25

Statistical Methods for Analyzing Epidemiological Data

Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
1.3K
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by...
1.7K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.7K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.7K
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.6K