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Platelet-to-Lymphocyte Ratio Predicts Contrast-Induced Nephropathy in Patients With Non-ST-Segment Elevation Acute

Cuneyt Kocas1, Ahmet Yildiz2, Okay Abaci1

  • 1Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.

Angiology
|April 9, 2015
PubMed

Insights

The platelet-to-lymphocyte ratio (PLR) is a significant predictor of contrast-induced nephropathy (CIN) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Higher PLR levels indicate an increased risk of developing CIN after angiography.

Area of Science:

  • Cardiology
  • Nephrology
  • Hematology

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication following angiography.
  • Non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients undergoing angiography are at risk for CIN.
  • The platelet-to-lymphocyte ratio (PLR) is an emerging inflammatory marker.

Purpose of the Study:

  • To investigate the association between admission platelet-to-lymphocyte ratio (PLR) and CIN in NSTE-ACS patients.
  • To identify predictors of CIN in patients undergoing urgent coronary angiography for NSTE-ACS.

Main Methods:

  • Retrospective analysis of 488 NSTE-ACS patients undergoing urgent coronary angiography.
  • Measurement of PLR and creatinine levels pre-angiography and 72 hours post-angiography.
  • Logistic regression analysis to determine independent predictors of CIN.

Main Results:

  • 80 patients (16.3%) developed CIN.
  • Patients in the CIN group had significantly higher admission PLR compared to the non-CIN group (152.9 ± 99.6 vs 120.4 ± 66.1, P < .001).
  • Admission PLR, diabetes mellitus, and ST-segment depression were independent predictors of CIN.

Conclusions:

  • Admission PLR is an independent predictor of CIN in NSTE-ACS patients.
  • Elevated PLR may indicate increased risk for CIN post-angiography.
  • PLR could serve as a valuable biomarker for stratifying CIN risk in this patient population.

Keywords:
acute coronary syndromecontrast-induced nephropathyplatelet-to-lymphocyte ratio

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