Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Perinatal Stress to Schizophrenia: The Emerging Role of Glial Pathology.

Annals of neurosciences·2026
Same author

Association of HLA class I allele and tuberculosis susceptibility: a systematic review and meta-analysis.

Scientific reports·2025
Same author

Microglial Dystrophy and Spatial Learning Impairments Following Exposure to Multiple Early-life Stressors in Rats.

Annals of neurosciences·2025
Same author

Multiple Early Life Stressors as Risk Factors for Neurodevelopmental Abnormalities in the F1 Wistar Rats.

Brain sciences·2023
Same author

Astrogliosis and associated CSPG upregulation adversely affect dendritogenesis, spinogenesis and synaptic activity in the cerebellum of a double-hit rat model of protein malnutrition (PMN) and lipopolysaccharide (LPS) induced bacterial infection.

Journal of chemical neuroanatomy·2023
Same author

Perineuronal nets: Cruise from a honeycomb to the safety nets.

Brain research bulletin·2022

Related Experiment Video

Updated: Apr 15, 2026

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
09:12

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Published on: November 14, 2018

8.4K

Differential temporal expression of S100β in developing rat brain.

Nisha Patro1, Aijaz Naik2, Ishan K Patro2

  • 1School of Studies in Neuroscience, Jiwaji University Gwalior, India.

Frontiers in Cellular Neuroscience
|April 9, 2015
PubMed
Summary

S100β is a promising marker for identifying radial progenitor cells during brain development. This study demonstrates its dynamic expression throughout neurogenesis and early gliogenesis.

Keywords:
GFAPS100βastrocytenestinneural development

More Related Videos

Author Spotlight: Collecting Neural Stem and Progenitor Cells from Live Animals Using a Novel Brain Milking Protocol
06:52

Author Spotlight: Collecting Neural Stem and Progenitor Cells from Live Animals Using a Novel Brain Milking Protocol

Published on: February 9, 2024

2.8K
Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
11:52

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Published on: February 9, 2017

6.6K

Related Experiment Videos

Last Updated: Apr 15, 2026

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
09:12

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Published on: November 14, 2018

8.4K
Author Spotlight: Collecting Neural Stem and Progenitor Cells from Live Animals Using a Novel Brain Milking Protocol
06:52

Author Spotlight: Collecting Neural Stem and Progenitor Cells from Live Animals Using a Novel Brain Milking Protocol

Published on: February 9, 2024

2.8K
Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
11:52

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Published on: February 9, 2017

6.6K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Radial glial cells (RGs) are crucial precursors for neurons and glia.
  • Identifying specific markers for RGs is essential for understanding brain development.
  • Previous markers like GFAP are not suitable for early RG identification.

Purpose of the Study:

  • To investigate S100β as a unified marker for primary and secondary progenitor cells.
  • To determine the spatiotemporal expression of S100β during neurogenesis and gliogenesis.
  • To evaluate the suitability of S100β as a radial progenitor cell marker.

Main Methods:

  • Immunohistochemical labeling of rat brain sections from embryonic to postnatal ages.
  • Co-expression analysis of S100β with Nestin and GFAP.
  • Assessment of dynamic protein expression patterns during development.

Main Results:

  • S100β co-expressed with Nestin in primary and secondary progenitors in the VZ and SVZ.
  • Downregulation of S100β and Nestin correlated with cell differentiation.
  • GFAP did not co-express with S100β or Nestin, ruling it out as an early RG marker.
  • S100β expression dynamic: present in proliferating progenitors, repressed upon differentiation, re-emerges in mature astrocytes.

Conclusions:

  • S100β is dynamically expressed in neural stem cells and radial glial cells during embryonic and early neonatal development.
  • S100β expression is linked to proliferative potential and migration of neuroblasts and astrocytes.
  • S100β is a suitable marker for radial progenitor cells throughout neurogenesis and early gliogenesis.