Modulating pathological oscillations by rhythmic non-invasive brain stimulation-a therapeutic concept?
Lutz A Krawinkel1, Andreas K Engel2, Friedhelm C Hummel3
1BrainImaging and NeuroStimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf Hamburg, Germany.
Frontiers in Systems Neuroscience
|April 9, 2015
Summary
This review explores how brain
Area of Science:
- Neuroscience
- Neurology
- Psychiatry
Background:
- Human behavior is linked to brain oscillatory activity.
- Abnormal brain oscillations correlate with neuropsychiatric disorders like Parkinson's disease (PD) and schizophrenia (SCZ).
- Non-invasive brain stimulation (NIBS) shows promise for improving behavior in these patients.
Purpose of the Study:
- To review oscillatory changes in patients with stroke, PD, and SCZ.
- To discuss interventional strategies targeting abnormal brain oscillations.
- To explore how NIBS can modulate oscillations and behavior.
Main Methods:
- Literature review of studies on brain oscillations and neuropsychiatric disorders.
- Analysis of research on non-invasive brain stimulation (NIBS) techniques.
- Synthesis of findings on oscillatory abnormalities and behavioral deficits.
Main Results:
- Oscillatory abnormalities are documented in stroke, PD, and SCZ.
- NIBS has the potential to modulate these oscillations.
- Modulating oscillations may improve related pathological behaviors.
Conclusions:
- Targeting pathological brain oscillations with NIBS is a promising therapeutic avenue.
- Further research is needed to refine NIBS strategies for neuropsychiatric disorders.
- This review highlights potential interventional approaches for improving patient outcomes.
