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Effects of pioglitazone or exercise in older adults with mild cognitive impairment and insulin resistance: a pilot
Kerry L Hildreth1, Rachael E Van Pelt1, Kerrie L Moreau1
1Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USA.
Aims:
To examine the effects of pioglitazone or endurance exercise training on cognitive function in older adults with mild cognitive impairment (MCI) and insulin resistance.
Methods:
Seventy-eight adults (mean age ± SD: 65 ± 7 years) with central obesity and MCI were randomized to 6 months of endurance exercise, pioglitazone or control.
Results:
Sixty-six participants completed the study. Exercise training did not significantly increase peak oxygen uptake compared to control (p = 0.12). Compared to control, insulin resistance improved in the pioglitazone group (p = 0.002) but not in the exercise group (p = 0.25). There was no measureable effect of pioglitazone or exercise on cognitive performance compared to control.
Conclusion:
In this pilot study, pioglitazone improved insulin resistance but not cognitive performance in older adults with MCI and insulin resistance.
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