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Related Experiment Video

Updated: Apr 15, 2026

Primary Tumor and MEF Cell Isolation to Study Lung Metastasis

Primary Tumor and MEF Cell Isolation to Study Lung Metastasis

Published on: May 20, 2015

EMT and tumor metastasis.

Sarah Heerboth¹, Genevieve Housman², Meghan Leary¹

¹Cancer Center, Department of Medicine, Boston University School of Medicine, Boston, MA USA.

Clinical and Translational Medicine

|April 9, 2015

Summary

Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are key cellular processes in development and cancer. Reversible epigenetic events are hypothesized to regulate these transitions and metastatic cancer development.

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Last Updated: Apr 15, 2026

Primary Tumor and MEF Cell Isolation to Study Lung Metastasis

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Induction and Analysis of Epithelial to Mesenchymal Transition

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

Area of Science:

Cellular biology
Developmental biology
Cancer research

Background:

Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are fundamental cellular processes.
These transitions are crucial for normal development and cancer metastasis.

Purpose of the Study:

To review EMT and MET processes and their molecular pathways.
To compare these processes in embryogenesis and cancer metastasis.
To discuss the clinical implications and epigenetic regulation of EMT/MET.

Main Methods:

Comparative analysis of embryogenesis and cancer metastasis.
Discussion of signaling pathways and receptor expression.
Exploration of epigenetic mechanisms.

Main Results:

EMT and MET involve complex molecular pathways and receptor dynamics.
Clinical implications of EMT/MET are observed across various tumor types.
Epigenetic events play a significant role in regulating EMT/MET.

Conclusions:

EMT and MET are integral to both development and cancer.
Reversible epigenetic events are hypothesized to control EMT/MET and metastatic cancer progression.