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Updated: Apr 15, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Sarcoidosis presenting as severe renin-dependent hypertension due to kidney vascular injury
Cedric Rafat1, Guillaume Bobrie1, Antoine Chedid1
1Hypertension Unit , Université Paris Descartes, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou , Paris Cedex 15 , France.
Abstract:
Renal sarcoidosis embraces a wide variety of clinical patterns. Renal vascular involvement has seldom been reported and usually in the setting of systemic vasculitis. We report the case of a 22-year-old patient in whom inaugural manifestation of renal sarcoidosis consisted of severe hypertension associated with bilateral perfusion defects and tumour-like nodules. In the setting of renal sarcoidosis, our case suggests that renin-dependant hypertension may arise from renal ischaemia as a result of extrinsic compression of kidney blood vessels due to severe granulomatous inflammation.
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